A long-non-coding RNA, LINC00473, confers the human adipose tissue thermogenic phenotype through enhanced cAMP responsiveness.
K.-V. Tran, C. Nandrup-Bus, T. DeSouza, R. Soares, N. Z. Jespersen, S. Y. Min, R. Rojas-Rodriguez, H. Willenbrock, T. Juhlin, M. C. K. Severinsen, K. Malka, B. K. Pedersen, T. Fitzgibbons, C. Scheele, S. Corvera, S. Nielsen
This study identifies LINC00473 as a key regulator of thermogenic adipocyte function, showing its role in enhancing cAMP responsiveness and mitochondrial activity.
bioRxiv · Jun 5, 2018Cell Biology