Author

R. Soares

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

B. K. Pedersen· 2 shared C. M. Paquete· 2 shared C. Scheele· 2 shared N. Z. Jespersen· 2 shared S. Nielsen· 2 shared A. J. Whitworth· 1 shared A. Knebel· 1 shared A. Shaw· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

B. K. Pedersen

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6 papers

Recent·Most cited

A Survey of the Desulfuromonadia cytochromome provides a glimpse of the unexplored diversity of multiheme cytochromes in nature

R. Soares, B. M. Fonseca, B. W. Nash, C. M. Paquete, R. O. Louro

The paper surveys MHC diversity in Desulfuromonadia using bioinformatics and AlphaFold2, revealing many uncharacterized cytochromes with potential biotechnological applications.

bioRxiv · Jan 5, 2024 · PreprintBiochemistry

Regulation of Human PINK1 ubiquitin kinase by Serine167, Serine228 and Cysteine412 phosphorylation

A. Waddell, H. Ojha, S. Agarwal, C. Clarke, A. Terriente-Felix, H. Zhou, P. Kakade, A. Knebel, A. Shaw, R. Gourlay, J. Varghese, R. Soares, R. Toth, T. Macartney, P. Eyers, , M. Muqit

This study identifies phosphorylation sites in hPINK1 that regulate its activation and ubiquitin interaction, revealing a novel inhibitory mechanism involving pCys412.

bioRxiv · Mar 31, 2023 · PreprintBiochemistry

A new paradigm of multiheme cytochrome evolution by grafting and pruning protein modules

R. Soares, C. M. Paquete, N. Costa, C. Andreini, R. O. O. Louro

This study refines the evolutionary relationships of multiheme cytochromes by showing that NrfA and cytochrome c554 evolved from ancestral octaheme cytochromes through pruning and grafting of protein modules.

bioRxiv · Feb 24, 2022Biochemistry

Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesity

N. Z. Jespersen, M. W. Andersen, V. H. Jensen, T. W. Staerker, M. C. Severinsen, L. Peijs, R. Soares, I. Forss, E. S. Andersen, C. H. Hahn, P. Homee, S. Mandrup, B. K. Pedersen, S. Nielsen, C. Scheele

The paper identifies a reduction in thermogenic genes but preserved brown adipose tissue identity in human obesity through transcriptomic analysis of BAT and WAT.

bioRxiv · May 7, 2020 · PreprintCell Biology

Lathosterol oxidase (sterol C5-desaturase) deletion confers resistance to amphotericin B and sensitivity to acidic stress in Leishmania major

Y. Ning, C. Frankfater, F.-F. Hsu, R. Soares, C. Cardoso, P. Nogueira, N. Lander, R. Docampo, K. Zhang

This study shows that deleting LSO in Leishmania major confers amphotericin B resistance but causes sensitivity to acidic stress and membrane disruption.

bioRxiv · Apr 20, 2020Microbiology

A long-non-coding RNA, LINC00473, confers the human adipose tissue thermogenic phenotype through enhanced cAMP responsiveness.

K.-V. Tran, C. Nandrup-Bus, T. DeSouza, R. Soares, N. Z. Jespersen, S. Y. Min, R. Rojas-Rodriguez, H. Willenbrock, T. Juhlin, M. C. K. Severinsen, K. Malka, B. K. Pedersen, T. Fitzgibbons, C. Scheele, S. Corvera, S. Nielsen

This study identifies LINC00473 as a key regulator of thermogenic adipocyte function, showing its role in enhancing cAMP responsiveness and mitochondrial activity.

bioRxiv · Jun 5, 2018Cell Biology