C. Scheele

An ultrasound-guided biopsy technique for obtaining supraclavicular brown fat biopsies and preadipocytes

This paper describes an ultrasound-guided biopsy technique to collect supraclavicular brown fat and subcutaneous white fat from healthy individuals, and evaluates in vitro differentiation and gene expression of progenitor cells.

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

This study shows that autophagy in lymphatic endothelial cells controls T cell egress from lymph nodes, which is critical for immune checkpoint therapy effectiveness.

Thermogenic genes are blunted whereas brown adipose tissue identity is preserved in human obesity

The paper identifies a reduction in thermogenic genes but preserved brown adipose tissue identity in human obesity through transcriptomic analysis of BAT and WAT.

Proteomics-based comparative mapping of the human brown and white adipocyte secretome reveals EPDR1 as a novel batokine

The paper compares the secretomes of human brown and white adipocytes using proteomics, identifying EPDR1 as a novel batokine involved in thermogenesis and energy consumption.

Asymmetric perirenal brown adipose dormancy in adult humans is defined by local sympathetic activity

The paper identifies dormant brown adipose tissue in adult humans, characterized by unilocular morphology and distinct gene expression, and proposes mechanisms for its regulation and potential reactivation.

A long-non-coding RNA, LINC00473, confers the human adipose tissue thermogenic phenotype through enhanced cAMP responsiveness.

This study identifies LINC00473 as a key regulator of thermogenic adipocyte function, showing its role in enhancing cAMP responsiveness and mitochondrial activity.