K. Manjunath

Mutational scan inferred binding energetics and structure in intrinsically disordered protein CcdA

The paper uses deep mutational scanning to study sequence-function relationships in the IDP CcdA, revealing insights into binding energetics and structural signatures.

Structural and functional determinants inferred from deep mutational scans

The paper uses deep mutational scans to identify and distinguish protein binding sites from buried and non-active residues using a toxin-antitoxin system.

Mechanistic insights into global suppressors of protein folding defects

The paper identifies global suppressor mutations that rescue protein folding defects and shows they stabilize proteins through refolding rate acceleration, with some providing structural insights.

Stabilizing proteins through saturation suppressor mutagenesis.

This paper introduces a method to identify stabilizing protein mutations by screening libraries with destabilizing mutations, demonstrating its effectiveness in enhancing protein stability.

Prediction of residue-specific contributions to binding and thermal stability using yeast surface display

The paper uses yeast surface display to predict residue-specific contributions to binding and thermal stability, showing high accuracy in identifying buried and active-site residues.