P. Goyal

Molecular determinants of Neu5Ac binding to tripartite ATP independent periplasmic (TRAP) transporter

The paper reports the structures of SiaQM from Fusobacterium nucleatum with and without Neu5Ac, revealing interactions and transport mechanisms.

Mosquitoes escape looming threats by actively flying with the bow-wave induced by the attacker

This study shows that mosquitoes detect and escape looming threats using airflow sensing and actively fly with the attacker's bow-wave to avoid collision.

A Biotin Targeting Chimera (BioTAC) System to Map Small Molecule Interactomes in situ

The paper introduces the BioTAC system to map small molecule interactomes in situ, enabling the identification of both direct and complexed binding proteins with high confidence.

Bumblebees actively compensate for the adverse effects of sidewind during visually-guided landings

This study shows bumblebees adjust their landing strategies in sidewinds to maintain precision, using both mechanosensory and visual inputs.

Computational and biochemical analyses reveal that cofilin-2 self assembles into amyloid-like structures and promotes the aggregation of other proteinaceous species: Pathogenic relevance to myopathies

This study shows cofilin-2 can form amyloid-like structures and promote protein aggregation, suggesting a role in myopathies.

Mechanistic insights into global suppressors of protein folding defects

The paper identifies global suppressor mutations that rescue protein folding defects and shows they stabilize proteins through refolding rate acceleration, with some providing structural insights.

Coiled-coil registry shifts in the F684I mutant of Bicaudal result in cargo-independent activation of dynein motility

The paper shows that a coiled-coil registry shift in the F684I mutant of BicD activates dynein motility without cargo, and suggests this mechanism may modulate cargo selection in BicD2.

Role of coiled-coil registry shifts in activation of human Bicaudal D2 for dynein recruitment upon cargo-binding

This paper investigates how coiled-coil registry shifts in BicD2 activate dynein recruitment upon cargo-binding, linking structural changes to disease mechanisms.