S. Chandra

An Automated and Robust Tool for Musculoskeletal and Finite Element Modeling of the Knee Joint

The paper develops an automated knee musculoskeletal finite element modeling pipeline and compares two approaches for generating biomechanical models.

Mutational scan inferred binding energetics and structure in intrinsically disordered protein CcdA

The paper uses deep mutational scanning to study sequence-function relationships in the IDP CcdA, revealing insights into binding energetics and structural signatures.

A Mitochondrial Inside-Out Iron-Calcium Signal Reveals Drug Targets for Parkinsons Disease

This study identifies a mitochondrial iron-calcium signaling mechanism in Parkinson's disease and discovers drug targets using Miro1-based screens and genetic analysis.

Transcriptomes and metabolism define mouse and human MAIT cell heterogeneity

This study identifies MAIT cell heterogeneity in mice and humans through single-cell RNA sequencing and metabolic analysis, revealing distinct transcriptomes and metabolic states in different tissues and species.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

Specialized subsets of innate-like T cells and dendritic cells protect from lethal pneumococcal infection in the lung

The paper identifies specialized innate-like T cells and dendritic cells that contribute to protection against pneumococcal lung infection through specific cytokine production and cellular interactions.

Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome

This study identifies Atg39 as a cargo adaptor that targets inner nuclear membrane components for autophagy by forming lumenal vesicles in the nuclear envelope.

Genome-Wide Identification and Characterization of MLO Gene Family in Octoploid Strawberry

This study identifies and characterizes MLO gene family in diploid and octoploid strawberry, revealing potential susceptibility sources and eQTL associations with MLO transcript levels.

Lipin-1 contributes to IL-4 mediated macrophage polarization

This study shows that lipin-1's transcriptional co-regulator activity is necessary for macrophage polarization and wound healing, as its absence impairs IL-4 mediated gene expression and tissue repair.