The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration
F. C. Pereira, X. Ge, J. M. Kristensen, R. H. Kirkegaard, K. Maritsch, Y. Zu, M. Decorte, B. Hausmann, D. Berry, K. Wasmund, A. Schintlmeister, T. Boettcher, J.-X. Cheng, M. Wagner
This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.
bioRxiv · Nov 12, 2023 · PreprintMicrobiology