J.-X. Cheng

The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration

This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.

High-throughput single-cell sorting by stimulated Raman-activated cell ejection

This paper introduces a high-throughput single-cell sorting platform using stimulated Raman-activated cell ejection, achieving high yield and purity in sorting polymer beads, bacteria, fungi, and tissue sections.

Nanoscale Structural Mapping of Protein Aggregates in Live Cells Modeling Huntington's Disease

This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.

Metagenomic analysis of individual mosquitos reveals the ecology of insect viruses

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

Stimulated Raman Photothermal Microscopy towards Ultrasensitive Chemical Imaging

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

Video-rate Mid-infrared Photothermal Imaging by Single Pulse Photothermal Detection per Pixel

This paper introduces a single pulse photothermal microscope for video-rate mid-infrared imaging, enabling observation of lipid dynamics and mapping fat storage in living systems.

Fingerprint SRS Imaging Unveils Ergosteryl Ester as a Metabolic Signature of Azole-Resistant Candida albicans

This paper identifies ergosteryl ester accumulation as a metabolic signature of azole-resistant Candida albicans using fingerprint SRS imaging and demonstrates a dual therapeutic strategy to suppress its viability.

Wireless Neuromodulation at Submillimeter Precision via a Microwave Split-Ring Resonator

This paper introduces a microwave split-ring resonator that enables submillimeter precision neuromodulation by enhancing microwave field localization and efficiency for inhibiting neurons.

Visualization of a Limonene Synthesis Metabolon inside Living Bacteria by Hyperspectral SRS Microscopy

The paper visualizes limonene synthesis metabolons in engineered E. coli using hyperspectral SRS microscopy and confirms colocalization with limonene synthase.

Single-shot Volumetric Chemical Imaging by Mid- Infrared Photothermal Fourier Light Field Microscopy

This paper introduces MIP-FLF microscopy to enable fast, volumetric infrared spectroscopic imaging of living cells and organisms, revealing lipid metabolism changes in drug-resistant pancreatic cancer cells.

The Balance between Saturated and Unsaturated Fatty Acids Regulates Ovarian Cancer Cell Fate

This study shows that the balance between saturated and unsaturated fatty acids, regulated by SCD, affects ovarian cancer cell survival and tumor progression, with UFAs protecting against ER stress-induced apoptosis.

LIPA-driven hydrolysis of cholesteryl arachidonate promotes cancer metastasis via NF-κB

This study identifies LIPA as a key regulator of CE hydrolysis in cancer cells, showing that its inhibition suppresses metastasis via suppression of NF-κB signaling.

Photoinactivation of catalase sensitizes Candida albicans and Candida auris to ROS-producing agents and immune cells

This study shows that photoinactivating catalase in fungi makes them more susceptible to ROS and immune cells, offering a new approach to treat drug-resistant fungal infections.

SRS-FISH: High-Throughput Platform Linking Microbiome Function to Identity at the Single Cell Level

The paper introduces SRS-FISH, a high-throughput imaging method to analyze microbial function at the single-cell level, showing Bacteroidales dominate sugar utilization but Clostridia outperform them in fucose foraging.

Photoinactivation of Catalase Sensitizes Wide-Ranging Bacteria to ROS-Producing Agents and Immune Cells

This study shows that blue light inactivates catalase in bacteria, making them vulnerable to ROS and immune cells, and validates this in a mouse model.

Metabolic Reprogramming from Glycolysis to Fatty Acid Uptake and beta-Oxidation in Platinum-Resistant Cancer Cells

The paper identifies metabolic reprogramming in platinum-resistant cancer cells from glycolysis to fatty acid uptake and beta-oxidation, showing a correlation with resistance and proposing a treatment strategy.

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis

The paper identifies FZD7 as a marker of platinum-tolerant ovarian cancer cells that are susceptible to ferroptosis via the FZD7-β-catenin-Tp63-GPX4 pathway.

A Thermodynamic Interpretation of the Stimulated Raman Spectroscopic Signature to Action Potential in Single Neurons

The paper uses hyperspectral stimulated Raman spectroscopy to show that neuronal membrane thermodynamic state changes during action potentials, supporting the acoustic hypothesis.

Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae

This study shows that photobleaching granadaene in Streptococcus agalactiae reduces its virulence and increases antimicrobial susceptibility to antibiotics and macrophage killing.

Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA

This study uses photo-disassembly of membrane microdomains to restore antibiotic susceptibility in MRSA, enabling conventional antibiotics to inhibit resistance development.

Rapid Determination of Antibiotic Susceptibility by Stimulated Raman Scattering Imaging of D2O Metabolism

This paper demonstrates a rapid method for antibiotic susceptibility testing using stimulated Raman scattering imaging of D2O metabolism in bacteria.