M. Wagner

ER-stress signaling and Alzheimer's proteins adjust the quality of human protein synthesis

The paper shows that ribosomal error-rate adapts in human aging models but not in mouse models, involving ER-stress signaling and Alzheimer's proteins.

Acidotolerant soil nitrite oxidiser 'Candidatus Nitrobacter laanbroekii' NHB1 alleviates constraints on growth of acidophilic soil ammonia oxidisers

This study characterizes the growth of Nitrobacter strain NHB1 under acidic conditions and shows its role in enhancing ammonia oxidation by acidophilic archaea in co-culture.

Microflora Danica: the atlas of Danish environmental microbiomes

Microflora Danica compiles 10,686 shotgun metagenomes and 449 rRNA datasets to create an atlas of Danish environmental microbiomes, revealing hidden homogeneity and novel nitrifiers.

Development, validation and application of an LC-MS/MS method quantifying free forms of the micronutrients queuine and queuosine in human plasma using a surrogate matrix approach

The paper develops and validates an LC-MS/MS method to quantify free queuine and queuosine in human plasma, finding no detectable Q but significant q levels with no gender difference.

Migration of endocrine and metabolism disrupting chemicals from plastic food packaging

This study investigates the migration of endocrine and metabolism disrupting chemicals from plastic food contact articles into food simulants, identifying potential endocrine disruptors and prioritizing chemicals for further analysis.

Global abundance patterns, diversity, and ecology of Patescibacteria in wastewater treatment plants

The paper improves 16S rRNA gene primers to better detect Patescibacteria in wastewater treatment plants, revealing their global diversity and potential ecological roles.

The predicted secreted proteome of activated sludge microorganisms indicate distinct nutrient niches

The paper predicts secreted proteomes of activated sludge microorganisms to identify nutrient niches, finding distinct enzyme profiles among microbial taxa.

Nitrous oxide respiration in acidophilic methanotrophs

This study shows that two acidophilic methanotrophs can respire N2O and grow anaerobically, expanding their ecological niche and offering potential for greenhouse gas mitigation.

Candidatus Nitrosocosmicus members are the dominant archaea associated with pepper (Capsicum annuum L.) and ginseng (Panax ginseng C.A. Mey.) plants rhizospheres

The paper identifies Candidatus Nitrosocosmicus as dominant ammonia-oxidizing archaea in rhizospheres of pepper and ginseng, showing their MnKat gene abundance and catalytic activity.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Novel nitrifying symbiont lineages are vertically inherited and widespread in marine sponges

This study identifies two novel nitrifying symbiont lineages in marine sponges, showing vertical transmission and suggesting their role in nitrogen cycling.

The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration

This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.

Beyond the nucleus: Plastic chemicals activate G protein-coupled receptors

This study identifies plastic chemicals as activators of G protein-coupled receptors, with mixtures showing strong activity at ADORA1 and MTNR1A.

Plastic food packaging from five countries contains endocrine and metabolism disrupting chemicals

The paper analyzes chemicals in plastic food packaging from five countries and finds endocrine and metabolism disrupting chemicals are prevalent.

A molecular toolbox to study progesterone receptor signaling

The paper develops sensitive tools to measure and visualize progesterone receptor (PR) signaling in breast epithelial cells, showing improved quantification and single-cell visualization.

Miniaturized CAR knocked onto CD3epsilon extends TCR function with CAR specificity under control of endogenous TCR signaling cascade

This paper describes a method to miniaturize CAR T cells by integrating only the antigen-binding domain under the control of the endogenous TCR signaling cascade, preserving TCR function while enabling CAR specificity.

Human TRMT2A methylates tRNA and contributes to translation fidelity

This study identifies TRMT2A as a tRNA methyltransferase that contributes to translation fidelity by modifying tRNA with m5U at position 54.

Ras-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy

This study identifies how pathogenic RIT1 mutations drive RAF-MAPK hyperactivation in Noonan syndrome, showing MEK inhibition can alleviate cardiac hypertrophy in a mouse model.

What is particular about microplastics? A meta-analysis of the toxicity of microplastics and suspended sediments

This paper compares the toxicity of microplastics to suspended sediments through meta-analysis and finds MP toxicity is about one order of magnitude higher, though with large uncertainties.

Taurine as a key intermediate for host-symbiont interaction in the tropical sponge Ianthella basta

The paper shows that taurine is a key intermediate in the metabolic exchange between the sponge Ianthella basta and its microbial symbionts, supporting sulfur cycling and nutrient transfer.

Engineering a Sinorhizobium meliloti chassis with monopartite, single replicon genome configuration

The paper simplifies the multipartite genome of Sinorhizobium meliloti by creating bi- and monopartite configurations, showing that monopartite genomes can be functional but have growth and localization issues.

Effects of microplastics mixed with natural particles on Daphnia magna populations

This study shows that exposure to microplastics and natural particles negatively affects Daphnia magna populations, with diatomite mixtures being more toxic than microplastics alone.

Expression variations in Ectodysplasin-A gene (eda) may contribute to morphological divergence of scales in Haplochromine cichlids

The paper investigates how expression variations in the eda gene contribute to morphological differences in scales among haplochromine cichlid species.

Adipogenic activity of chemicals used in plastic consumer products

The paper identifies MDCs in everyday plastics that promote adipogenesis, suggesting plastics as an underestimated contributor to obesity.

SRS-FISH: High-Throughput Platform Linking Microbiome Function to Identity at the Single Cell Level

The paper introduces SRS-FISH, a high-throughput imaging method to analyze microbial function at the single-cell level, showing Bacteroidales dominate sugar utilization but Clostridia outperform them in fucose foraging.

The diversity of quinoa morphological traits and seed metabolic composition

This study analyzes the seed metabolomes and agronomic traits of 471 quinoa cultivars to identify genetic diversity for breeding and genome editing.

Synthesis and Structure Elucidation of the Human tRNA Nucleoside Mannosyl-Queuosine

The paper reports the correct structure of mannosyl-queuosine (manQ) through total synthesis and LC-MS-co-injection, revealing a novel -allyl connectivity and differing glycosylase preferences.

How do symbiotic associations in lecideoid lichens respond to different environmental conditions along the Transantarctic Mountains, Ross Sea region, Antarctica?

This study examines how lecideoid lichens and their symbiotic partners respond to environmental conditions along the Transantarctic Mountains, finding that macroclimate drives species distribution and diversity.

A new twist in ABC transporter mediated multidrug resistance - Pdr5 is a drug/proton co-transporter

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

A simple coloring method to distinguish colonies of the yeasts Lachancea thermotolerans and Saccharomyces cerevisiae on agar media

The paper introduces a simple method using bromocresol purple to visually distinguish Lachancea thermotolerans and Saccharomyces cerevisiae colonies on agar media based on color change.