X. Ge

SS18::SSX redistributes BAF chromatin remodelers selectively to activate and repress transcription

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

Click-free imaging of carbohydrate trafficking in live cells using an azido photothermal probe

This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.

Phylogenomics resolves a 100-year-old debate regarding the evolutionary history of caddisflies (Insecta: Trichoptera)

This study resolves a century-old debate on caddisfly phylogeny by analyzing genome data from 111 species, clarifying the evolutionary relationships of 'cocoon-makers' and estimating divergence times.

The Parkinson's drug entacapone disrupts gut microbiome homeostasis via iron sequestration

This study shows that the Parkinson's drug entacapone disrupts gut microbiome homeostasis by sequestering iron, affecting microbial metabolism and promoting iron-scavenging organisms with resistance genes.

Glioblastoma Margin as a Diffusion Barrier Revealed by Photoactivation of Plasmonic Nanovesicles

This study uses plasmonic nanovesicles to measure diffusion in GBM and finds the tumor margin has the lowest diffusion coefficient, indicating it acts as a diffusion barrier.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

High-throughput single-cell sorting by stimulated Raman-activated cell ejection

This paper introduces a high-throughput single-cell sorting platform using stimulated Raman-activated cell ejection, achieving high yield and purity in sorting polymer beads, bacteria, fungi, and tissue sections.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Immunities Specific to Both of the M Protein Ectodomain and RBD Synergize to Confer Cross-protection against SARS-CoV-2 Infections

This study identifies conserved M protein peptides that elicit cross-neutralizing antibodies against multiple SARS-CoV-2 variants, including Omicron, when combined with RBD-specific antibodies.

Second messenger c-di-AMP regulates multiple antibiotic sensitivity pathways in Mycobacterium smegmatis by discrete mechanisms

This study shows that c-di-AMP modulates antibiotic sensitivity in M. smegmatis by interacting with protein effectors or mRNA 5-UTR regions, leading to differential drug resistance.

GRK2 Kinases in the Primary Cilium Initiate SMOOTHENED-PKA Signaling in the Hedgehog Cascade

This study identifies GRK2-mediated phosphorylation of SMO in the primary cilium as a critical step initiating SMO-PKA signaling in the Hedgehog pathway.

The novel roles of bovine milk-derived exosomes on skin anti-aging

This study investigates the effects of bovine milk-derived exosomes on human skin anti-aging, showing they enhance moisture retention and reduce wrinkles while being safe for use.

Geographic variation in evolutionary rescue in a predator-prey system under climate change: an example with aphids and ladybird beetles

The paper develops an eco-evolutionary model to study geographic variation in evolutionary rescue in a predator-prey system under climate change, finding that ladybirds are more likely to be rescued in southeastern locations.

Stimulated Raman Photothermal Microscopy towards Ultrasensitive Chemical Imaging

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

Noise-robust, physical microscopic deconvolution algorithm enabled by multi-resolution analysis regularization

This paper introduces noise-robust deconvolution algorithms for fluorescence microscopy using multi-resolution analysis regularization, improving resolution and SNR across various imaging techniques.

A novel purity analysis method of bovine milk-derived exosomes by two-dimensional high-performance liquid chromatography

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

Determination of oligomeric organization of membrane proteins from native membranes at nanoscale-spatial and single-molecule resolution

This paper introduces a single-molecule imaging technique to measure membrane protein oligomerization in native membranes at high spatial resolution.

Visualization of mitochondrial cristae and mtDNA evolvement and interactions with super-resolution microscopy

This study uses super-resolution microscopy to visualize mitochondrial cristae and mtDNA interactions, revealing their dynamic relationship and distribution patterns under different cellular conditions.

An oral vaccine for SARS-CoV-2 RBD mRNA-bovine milk-derived exosomes induces a neutralizing antibody response in vivo

An oral mRNA vaccine using bovine milk-derived exosomes encoding SARS-CoV-2 RBD induces neutralizing antibodies in mice.

Open-3DSIM: an Open-source three-dimensional structured illumination microscopy reconstruction platform

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

Exploring the genome and protein space of viruses

The paper estimates the genetic diversity of viruses using simulated discovery processes, finding that less than 3% of viral genetic diversity has been uncovered.

Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway

This study identifies Numb as a ciliary protein that promotes Hedgehog signaling by facilitating Ptch1 exit from the cilium through endocytic mechanisms.

Visualization of a Limonene Synthesis Metabolon inside Living Bacteria by Hyperspectral SRS Microscopy

The paper visualizes limonene synthesis metabolons in engineered E. coli using hyperspectral SRS microscopy and confirms colocalization with limonene synthase.

Optical Modulation of Blood-Brain-Tumor Barrier Permeability Enhances Drug Delivery in Diverse Preclinical Glioblastoma Models

This study demonstrates that optical modulation of the blood-brain-tumor barrier enhances drug delivery and suppresses tumor growth in glioblastoma models.

Molecular basis of broad neutralization against SARS-CoV-2 variants including Omicron by a human antibody

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

Predator-prey interactions in a warming world: the critical role of cold tolerance

This study examines how predator-prey interactions respond to climate change by analyzing thermal tolerance mismatches in ladybird beetles and aphids.

Potent antibody immunity to SARS-CoV-2 variants elicited by a third dose of inactivated vaccine

A third dose of inactivated SARS-CoV-2 vaccine significantly enhances plasma neutralization and generates high-affinity anti-RBD memory B cells against variants like Beta, Delta, and Lambda.

An atlas of human viruses provides new insights into diversity and tissue tropism of human viruses

The paper curates an atlas of human viruses, revealing increased diversity in infants and factors influencing tissue tropism, while introducing the Human Virus Database.

SRS-FISH: High-Throughput Platform Linking Microbiome Function to Identity at the Single Cell Level

The paper introduces SRS-FISH, a high-throughput imaging method to analyze microbial function at the single-cell level, showing Bacteroidales dominate sugar utilization but Clostridia outperform them in fucose foraging.

Clinical Strains of Pseudomonas aeruginosa secret LasB protease to induce hemorrhagic diffused alveolar damage and acute lung injury in mice

This study shows that Pseudomonas aeruginosa induces acute lung injury in mice through its LasB protease, causing hemorrhagic diffuse alveolar damage and hyaline membranes.