A pyridyl-furan series developed from Open Global Health Library blocks red blood cell invasion and protein trafficking in Plasmodium falciparum through potential inhibition of the parasites PI4KIIIb enzyme.
D. B. Ling, W. Nguyen, O. Looker, Z. Razook, K. McCann, A. E. Barry, C. Scheurer, S. Wittlin, H. E. Bullen, B. S. Crabb, B. E. Sleebs, P. R. Gilson
The paper identifies a pyridyl-furan compound series that inhibits Plasmodium falciparum growth and red blood cell invasion by targeting the PI4KIIIb enzyme.
bioRxiv · Apr 25, 2023Microbiology