Author

O. Looker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:plant (other)· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. S. Crabb· 3 shared P. R. Gilson· 3 shared B. E. Sleebs· 2 shared H. E. Bullen· 2 shared A. Blanch· 1 shared A. E. Barry· 1 shared A. Low J.Y· 1 shared B. Liu· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

B. S. Crabb

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A pyridyl-furan series developed from Open Global Health Library blocks red blood cell invasion and protein trafficking in Plasmodium falciparum through potential inhibition of the parasites PI4KIIIb enzyme.

D. B. Ling, W. Nguyen, O. Looker, Z. Razook, K. McCann, A. E. Barry, C. Scheurer, S. Wittlin, H. E. Bullen, B. S. Crabb, B. E. Sleebs, P. R. Gilson

The paper identifies a pyridyl-furan compound series that inhibits Plasmodium falciparum growth and red blood cell invasion by targeting the PI4KIIIb enzyme.

bioRxiv · Apr 25, 2023Microbiology

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts.

M. P. Schneider, O. Looker, M. Rebelo, D. S. Khoury, M. W. Dixon, C. Oeuvray, B. S. Crabb, J. McCarthy, P. R. Gilson

This study shows M5717 delays Plasmodium falciparum parasite clearance by preventing host RBC modification, leading to reduced cytoadherence and splenic clearance.

bioRxiv · Apr 24, 2023 · PreprintMicrobiology

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

O. Looker, M. G. Dans, H. E. Bullen, B. E. Sleebs, B. S. Crabb, P. R. Gilson

The paper screens 400 anti-malarial compounds to identify inhibitors of protein export in Plasmodium falciparum, finding MMV396797 as a potent inhibitor that reduces parasite virulence.

bioRxiv · May 1, 2022Biochemistry

The Plasmodium falciparum protein VCAP1 controls Maurer’s cleft morphology, knob architecture and PfEMP1 trafficking

E. McHugh, O. Carmo, A. Blanch, O. Looker, B. Liu, S. Tiash, S. Batinovic, A. Low J.Y, P. McMillan, L. Tilley, M. Dixon

This study identifies VCAP1 as a key protein controlling Maurer’s cleft structure and PfEMP1 trafficking in Plasmodium falciparum, leading to altered parasite growth and RBC deformability.

bioRxiv · Aug 20, 2019Microbiology