BiophysicsbioRxiv
Liquid-liquid Phase Separation of Alpha-synuclein Increases the Structural Variability of Fibrils Formed during Amyloid Aggregation
M. Ziaunys, D. Sulskis, D. Veiveris…·V. Smirnovas
This study compares alpha-synuclein aggregation under conditions that promote or negate liquid-liquid phase separation, showing that phase separation leads to more structurally variable and toxic fibrils.
DOI 10.1111/febs.17244