Agonist and antagonist diverted twisting motions of single TRPV1 channel
S. Fujimura, K. Mio, M. Kuramochi, H. Sekiguchi, I. Keigo, M. Mio, K. Hengphasatporn, Y. Shigeta, T. Kubo, Y. C. Sasaki
The paper uses DXT to observe agonist and antagonist-induced rotational biases in TRPV1 channels, revealing opposing twisting motions and providing insights into TRP channel activation and modulation.
bioRxiv · Aug 18, 2020Biophysics