Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators
G. M. Kline, R. J. Paxman, C.-Y. Lin, N. Madrazo, J. M. Grandjean, K. Lee, K. Nugroho, E. Powers, L. Wiseman, J. W. Kelly
This study shows that AA132, a compound with a 2-amino-p-cresol substructure, globally activates all three UPR arms by covalently modifying ER PDIs, while AA147 selectively activates the ATF6 arm.
bioRxiv · Jan 16, 2023 · PreprintBiochemistry