Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Z. Khattar, N. Madrazo, E. Powers, J. D. Rosarda, L. Wiseman
The paper identifies the integrated stress response (ISR) as the primary signaling pathway activated by mitochondrial proteostasis stress using gene set profiling in Perturb-seq datasets.
bioRxiv · Jan 30, 2024Cell Biology
G. M. Kline, R. J. Paxman, C.-Y. Lin, N. Madrazo, J. M. Grandjean, K. Lee, K. Nugroho, E. Powers, L. Wiseman, J. W. Kelly
This study shows that AA132, a compound with a 2-amino-p-cresol substructure, globally activates all three UPR arms by covalently modifying ER PDIs, while AA147 selectively activates the ATF6 arm.
bioRxiv · Jan 16, 2023 · PreprintBiochemistry
A. Madhavan, B. P. Kok, J. M. Grandjean, V. Albert, A. Sukiasyan, B. Rius, E. Powers, A. Galmozzi, E. Saez, L. Wiseman
This study shows that pharmacologic activation of IRE1/XBP1s signaling in obese mice improves glucose metabolism, insulin action, and reduces hepatic steatosis and inflammation.
bioRxiv · Dec 3, 2020Physiology