J. Liang

Urine Proteomics in Methamphetamine Addicted Patients

This study compares urine proteomes of methamphetamine users, withdrawers, and healthy individuals, identifying differentially expressed proteins linked to addiction and neurotoxicity.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

CASTpFold: Computed Atlas of Surface Topography of the universe of protein Folds

CASTpFold extends the CASTp tool to provide accurate and comprehensive protein surface topography analysis using AlphaFold2 structures and functional annotations.

Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model

The paper investigates how exercise affects Alzheimer's disease in mice by analyzing gene expression and chromatin changes, finding that growth factor signaling pathways are key to exercise's benefits.

Divergence in a Eukaryotic Transcription Factor's co-TF Dependence Involves Multiple Intrinsically Disordered Regions

The paper examines how divergence in intrinsically disordered regions of a eukaryotic transcription factor affects its co-TF dependence across species.

Phaeocystis blooms caused carbon drawdown during the Antarctic Cold Reversal from sedimentary ancient DNA

This study uses ancient DNA analysis to show that Phaeocystis blooms contributed to carbon drawdown during the Antarctic Cold Reversal, linking sea-ice changes to productivity shifts.

Sarcomeric SRX:DRX Equilibrium in Alport and LDLR/P407 Mouse Models of HFpEF.

The paper quantifies SRX and DRX myosin states in HFpEF mouse models, finding altered SRX:DRX proportions linked to specific cardiac phenotypes.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

Discovery and characterization of chromosomal inversions in the arboviral vector mosquito Aedes aegypti

This study identifies chromosomal inversions in Aedes aegypti using Hi-C, revealing geographic distribution patterns and potential roles in host choice and disease transmission.

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

Selective Mitochondrial Respiratory Complex I Subunit Deficiency Causes Tumor Immunogenicity

This study shows that deleting specific mitochondrial Complex I subunits, Ndufs4 and Ndufs6, enhances tumor immunogenicity and sensitivity to immune checkpoint blockade in mouse melanoma models.

Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural Drosophila populations

This study examines mitonuclear interactions in Drosophila populations, finding that natural disruptions affect mitochondrial function and fitness traits like reproduction and survival.

Structural insights into abscisic acid exporter AtABCG25

The paper determines the structure of AtABCG25, an ABA exporter, revealing its mechanism of ABA binding and transport through cryo-EM.

Rationally designed multimeric nanovaccines using icosahedral DNA origami for molecularly controlled display of SARS-CoV-2 receptor binding domain

This study designs multimeric nanovaccines using icosahedral DNA origami to display SARS-CoV-2 RBD, showing enhanced B cell activation and immune responses in mice.

CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

Turicibacter strains differentially modify bile acids and host lipids

The paper characterizes Turicibacter strains' bile acid and lipid-modifying capabilities, showing strain-specific effects on host metabolism and lipid profiles.

Divergence of TORC1-mediated Stress Response Leads to Novel Acquired Stress Resistance in a Pathogenic Yeast

The paper identifies how phosphate starvation induces oxidative stress resistance in C. glabrata but not S. cerevisiae through rewired TORC1 signaling and TF networks.

A transcriptional cell atlas identifies the decline in the AT2 niche in aged human lungs

This study creates a single-cell transcriptional atlas of human lungs across ages, revealing age-related dysregulation in AT2 cells and their niche, including increased senescence and inflammation.

Automated cell annotation in multi-cell images using an improved CRF_ID algorithm

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

Opposing implications of co-evolutionary lineages and traits of gut microbiome on human health status

The paper compares co-evolutionary lineages of gut microbes in wild primates and humans, revealing opposing health implications of specific microbial traits.

Defining a critical role of an essential membrane protein in mycolic acid transport in mycobacteria

This study identifies MSMEG_0317 as essential for mycolic acid transport in Mycobacterium smegmatis, showing its role in maintaining the outer membrane structure.

Development of heat shock resistance in L. pneumophila modeled by experimental evolution

This study uses experimental evolution to model heat shock resistance in L. pneumophila, finding mutations in heat shock genes that confer survival under high temperatures.

Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury

This study investigates the role of IGF2R in myocardial ischemia-reperfusion injury, finding it promotes inflammation and fibrosis and is a potential therapeutic target.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

Semiconductor augumented valuable chemical photosynthesis from Rhodospirillum rubrum and mechanism study

This paper constructs a Rhodospirillum rubrum-CdS biohybrid system and investigates its enhanced photosynthetic activity and electron transfer mechanisms.

Single-cell RNA-sequencing identifies a novel subset of CD9+ reparative macrophages modulated by CCN2 derived from Nlrx1 deficient cardiomyocytes in the infarcted heart

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas

This paper develops a finite element model of the chinchilla inner ear to study how CI electrode insertion angle affects residual hearing, finding minimal hearing loss with optimal angles.

Peripheral extracellular vesicle-derived miR-150-3p exacerbates acute kidney injury following acute pancreatitis by promoting ferroptosis through FTH1 signaling

This study identifies miR-150-3p in extracellular vesicles as a mediator of ferroptosis in acute kidney injury following acute pancreatitis.