SP1 affects the migration and invasion of laryngeal cancer cells by regulating methylation of claudin 4 promoter region through the p-JNK pathway
H. Shi, J. Ni, K. Peng, Y. Liu, y. Liu
This study shows SP1 regulates CLDN4 promoter methylation via the p-JNK pathway, increasing MMP-2/MMP-9 expression and enhancing laryngeal cancer cell migration and invasion.
bioRxiv · Jul 20, 2022 · PreprintCancer Biology