Author

R. K. Mathew

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

H. Wurdak· 4 shared A. Droop· 3 shared S. C. Short· 3 shared B. da Silva· 2 shared E. S. Polson· 2 shared J. Williams· 2 shared L. F. Stead· 2 shared A. A. Melcher· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

H. Wurdak

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Author profile →

4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 20, 2020

The cell cycle state defines TACC3 as a regulator gene in glioblastoma

H. Briggs, E. Polson, B. K. Irving…·H. Wurdak

The paper identifies TACC3-dependent genes that correlate with poor survival in glioblastoma patients, revealing its role in cell cycle-regulated gene networks.

DOI 10.1101/2020.10.20.346643

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologybioRxivOct 4, 2019

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered natural killer cell phenotype in glioblastoma

H. J. Close, L. F. Stead, J. Nsengimana…·E. B. Wilson

DOI 10.1111/cei.13403

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivNov 10, 2018

Chemically-induced Neurite-like Outgrowth Reveals Multicellular Network Function in Patient-derived Glioblastoma Cells

B. da Silva, E. S. Polson, A. Droop…·H. Wurdak

The paper shows that ROCKi promotes neurite-like outgrowth in GBM cells, forming radiation-resistant multicellular networks that can be reversed.

DOI 10.1242/jcs.228452

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivOct 18, 2017

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

E. S. Polson, V. B. Kuchler, C. Abbosh…·H. Wurdak

The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.

DOI 10.1126/scitranslmed.aar2718

humanbulk RNA-seq

𝕏 PostBluesky