C. M. Heaphy

This paper introduces a chromogenic in situ hybridization method to measure telomere lengths in prostate tissues, aiding in the identification of precancerous lesions.

This study shows that TERT promoter hypomethylation and chromatin state differ in neuroblastoma based on telomere maintenance mechanisms, with repressive marks in long telomere-associated cells.

This study shows that combining NF1 and ATRX deficiency makes certain solid tumors vulnerable to ATR inhibition, especially those with alternative lengthening of telomeres.

This study identifies plasma exosomal miRNAs associated with T2D that induce EMT and immune checkpoint expression in prostate cancer cells.

This paper shows that photochemical pre-bleaching reduces autofluorescence in archival prostate tissues, improving multiplex immunofluorescence signal-to-noise.

The paper investigates differential mast cell phenotypes in benign and cancerous prostate tissues and links higher numbers of tryptase-only mast cells to worse oncologic outcomes.

The paper investigates TERT promoter methylation in cancer cells and finds that hypermethylation represses TERT expression, explaining modest telomerase activation in most cancers.