C. Davis

Stability and characterization of infectious monkeypox virus extracellular virions in vitro2and vivo; implications for transmission, pathogenesis and treatment

This study characterizes the stability and infectious properties of monkeypox and vaccinia virus extracellular virions in vitro and in vivo, highlighting strain- and cell line-dependent variations in their behavior.

Critical reproductive behaviors in Scaled Quail and Northern Bobwhite are affected by thermal variability and mean temperature

The paper examines how thermal variability and mean temperature affect incubation behaviors in Scaled Quail and Northern Bobwhite across different timescales, finding that high thermal variability reduces off-bout length and that behavioral responses vary with temporal scale.

Temperature elevation synergises with and enhances the type-I IFN-mediated restriction of MPXV

This study shows that fever enhances the host's type-I IFN response to restrict MPXV replication.

A strict requirement in proteasome substrates for spacing between ubiquitin tag and degradation initiation elements

The paper shows that the distance between ubiquitin tags and degradation initiation elements determines proteasome-mediated protein degradation efficiency.

Maresin 1 Repletion Improves Muscle Regeneration After Volumetric Muscle Loss

This study shows that Maresin 1 treatment reduces fibrosis and improves muscle regeneration after volumetric muscle loss by modulating inflammation.

Topical GZ21T inhibits the growth of actinic keratoses in a UVB induced model of skin carcinogenesis

This study evaluates a topical formulation of GZ17-6.02 (GZ21T) in a murine model of actinic keratoses, showing reduced lesion count and surface area, and prevention of progression to squamous cell carcinoma.

Dual inhibition of SHP2 and autophagy suppresses NF1-associated Malignant Peripheral Nerve Sheath Tumors

This study shows that combining SHP2 and autophagy inhibition effectively suppresses NF1-associated MPNSTs in mouse models, suggesting a potential new treatment approach.

Cis-membrane association of human ATG8 proteins N-terminus mediates autophagy

This study shows that the N-termini of lipidated ATG8 proteins associate with membranes in cis, which is essential for autophagosome expansion and efficient p62 degradation.

The TERT promoter is polycomb-repressed in neuroblastoma cells with long telomeres

This study shows that TERT promoter hypomethylation and chromatin state differ in neuroblastoma based on telomere maintenance mechanisms, with repressive marks in long telomere-associated cells.

Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient high-grade solid tumors

This study shows that combining NF1 and ATRX deficiency makes certain solid tumors vulnerable to ATR inhibition, especially those with alternative lengthening of telomeres.

Delimiting the cryptic diversity and host preferences of Sycophila parasitoid wasps associated with oak galls using phylogenomic data

Neutrophil and natural killer cell imbalances prevent muscle stem cell mediated regeneration following murine volumetric muscle loss

The study compares muscle injuries leading to regeneration or fibrosis, revealing that neutrophil-natural killer cell communication affects muscle stem cell repair.

COVID-19 mRNA vaccines drive differential Fc-functional profiles in pregnant, lactating, and non-pregnant women

This study examines how mRNA vaccines affect Fc-functional antibody profiles in pregnant, lactating, and non-pregnant women, finding delayed kinetics and altered immune responses in pregnant and lactating individuals.

COVID-19: A need for new rather than repurposed antiviral drugs.

This paper reviews 29 FDA-approved antiviral compounds for COVID-19 treatment, finds limited clinical efficacy of repurposed drugs, and highlights the need for novel antivirals.

Lipidomic Profiling Reveals an Age-Related Deficiency of Skeletal Muscle Proresolving Mediators that Contributes to Maladaptive Tissue Remodeling

This study identifies age-related deficiencies in proresolving mediators in skeletal muscle, leading to impaired regeneration and inflammation, and shows that RvD1 treatment can mitigate some adverse effects.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

Immunoresolvents Support Skeletal Myofiber Regeneration via Actions on Myeloid and Muscle Stem Cells

This study shows that resolvin D1 promotes skeletal muscle regeneration by modulating myeloid cells and muscle stem cells, improving recovery without directly affecting myogenesis.

Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.

Engineered Microbes to Sense and Respond to Enterotoxigenic Escherichia coli

This paper engineers non-pathogenic E. coli to detect ETEC using quorum sensing and cellulose encapsulation for environmental monitoring.

Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines

The paper analyzes mineral content in UK dog and cat foods, finding widespread non-compliance with EU guidelines and potential health risks.