Optimization and deoptimization of codons in SARS-CoV-2 and the implications for vaccine development
X. Wu, K. Shan, F. Zan, X. Tang, Z. Qian, J. Lu
This study analyzes codon usage changes in SARS-CoV-2 over time, finds that deoptimization may reduce protein expression, and designs codon-optimized mRNA vaccine candidates for Omicron variants.
bioRxiv · Sep 3, 2022Evolutionary Biology