X. Tang

Related PP2C phosphatases Pic3 and Pic12 negatively regulate immunity in tomato to Pseudomonas syringae

This study identifies Pic3 and Pic12 as PP2C phosphatases that negatively regulate tomato immunity against Pseudomonas syringae through flagellin-independent pathways.

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

Brain implantation of tissue-level-soft bioelectronics 1 via embryonic development

This paper introduces a stretchable microelectrode array that integrates into the developing brain, enabling long-term, stable neural activity tracking without disrupting development.

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi

This study identifies the Dsc ubiquitin ligase complex as a quality control mechanism at the Golgi that degrades orphaned proteins by assessing transmembrane domain hydrophobicity.

PRMT5 deficiency disturbs Nur77 methylation to inhibit endometrial stromal cell differentiation in recurrent implantation failure

This study shows PRMT5 deficiency disrupts Nur77 methylation, impairing endometrial stromal cell differentiation and contributing to recurrent implantation failure.

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

Unveiling unique microbial nitrogen cycling and novel nitrification drivers in coastal Antarctica

This study identifies unique microbial nitrogen cycling mechanisms in coastal Antarctica, highlighting the role of comammox Nitrospira in nitrification.

Biosynthesis- and Metabolomics-guided discovery of antimicrobial cyclopeptides against drug-resistant clinical isolates

This study discovers new Avi(Me)Cys-containing cyclopeptide antibiotics effective against drug-resistant bacteria using genome mining and metabolomics.

NGAL deficiency elicits Hemophilia-like bleeding and clotting disorder

This study shows NGAL deficiency causes Hemophilia-like bleeding and clotting issues by enhancing coagulation and suppressing antithrombin.

Metabolomic changes associated with acquired resistance to Ixodes scapularis

This study identifies metabolomic changes in guinea pigs with acquired resistance to Ixodes scapularis ticks, showing that tyrosine pathway components like HPLA contribute to resistance.

Microbiome Prevents Sudden Death Through Occult Cardiac Sub-micrometastasis in Mice

The paper shows that gut microbiota prevents sudden cardiac death in mice by suppressing occult cardiac sub-micrometastases.

The Arabidopsis BUB1/MAD3 family protein BMF3 requires BUB3.3 to recruit CDC20 to kinetochores in spindle assembly checkpoint signaling

This paper identifies BUB3.3's role in recruiting CDC20 to unattached kinetochores via interaction with BMF3 in Arabidopsis, revealing a unique SAC mechanism distinct from fungi and animals.

A Two-Filter Adaptation to Achieve Hemodiafiltration with Enhanced Performance

This paper adapts conventional HD machines to achieve HDF with improved urea clearance and comparable safety metrics.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Roles of Lipopolysaccharide Glycosyltransferases in Maintenance of Helicobacter pylori Morphology, Cell Wall Permeability, and Antimicobial Susceptibilities

This study investigates the roles of LPS glycosyltransferases in H. pylori morphology, cell wall permeability, and antimicrobial susceptibility, finding that their deletion alters morphology and increases susceptibility to certain antimicrobials.

Broadly effective ACE2 decoy proteins protect mice from lethal SARS-CoV-2 infection

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

cGAS-activating lupus autoantibody for cancer immunotherapy

This study shows a lupus anti-DNA autoantibody activates cGAS and improves survival in glioblastoma models by enhancing CD8+ T cell infiltration.

STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity

This study shows that STAT3 is essential for maintaining hematopoietic stem cell function by suppressing interferon signaling and myeloid skewing, and its loss leads to impaired hematopoietic activity.

Molecular evolution of protein sequences and codon usage in monkeypox viruses

This study investigates the molecular evolution of protein sequences and codon usage in monkeypox viruses, identifying positive selection, accelerated evolution, and codon deoptimization patterns.

Comparative transcriptome revealed potential genes related with drug resistance in Melanoma

The paper identifies SENP1 and Hippo signaling pathway activation as factors contributing to drug resistance in melanoma using transcriptomic and functional analyses.

Multiplex Epigenome Editing of MECP2 to Rescue Rett Syndrome Neurons

This study uses multiplex epigenome editing to reactivate MECP2 from the inactive X chromosome in RTT neurons, rescuing neuronal defects in vitro.

The entry of pinewood nematode is linked to programmed tracheal development of vector beetles

This study links nematode entry into beetles to programmed tracheal development, showing gene expression changes and hormone activation facilitate nematode transmission.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

Optimization and deoptimization of codons in SARS-CoV-2 and the implications for vaccine development

This study analyzes codon usage changes in SARS-CoV-2 over time, finds that deoptimization may reduce protein expression, and designs codon-optimized mRNA vaccine candidates for Omicron variants.

PLK1 O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma

This study identifies PLK1 O-GlcNAcylation as critical for cell division and shows its role in suppressing uterine carcinoma through biochemical and mouse model experiments.

Integration of multi-omics data shows downregulation of mismatch repair, purin, and tublin pathways in AR-negative triple-negative chemotherapy-resistant breast tumors

The paper identifies a 17-gene signature from post-NAC biopsies that shows downregulation of immune and pathway genes associated with TNBC recurrence.

Sequential functional differentiation of luminal epithelial cells regulated by maternal and embryonic signaling in the mouse endometrium

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.