AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells
R. A. Hampsch, J. D. Wells, N. A. Traphagen, C. F. McCleery, J. L. Fields, K. Shee, L. M. Dillon, D. B. Pooler, L. D. Lewis, E. Demidenko, Y. H. Huang, J. D. Marotti, W. Kinlaw, T. W. Miller
This study shows that metformin promotes survival of dormant ER+ breast cancer cells by increasing mitochondrial respiration through fatty acid oxidation, suggesting caution in using AMPK activators with anti-estrogens.
bioRxiv · Jan 21, 2020Cancer Biology