Author

E. Demidenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

N. A. Traphagen· 2 shared T. W. Miller· 2 shared A. E. Goen· 1 shared A. Jiang· 1 shared A. L. Johnson· 1 shared A. M. Roberts· 1 shared B. A. Romo· 1 shared C. F. McCleery· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

N. A. Traphagen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Estrogen therapy induces receptor-dependent DNA damage enhanced by PARP inhibition in ER+ breast cancer

N. A. Traphagen, G. N. Schwartz, S. Tau, A. Jiang, S. R. Hosford, A. E. Goen, A. M. Roberts, B. A. Romo, A. L. Johnson, E.-C. K. Duffy, E. Demidenko, P. Heverly, Y. Mosesson, S. M. Soucy, F. Kolling, T. W. Miller

This study shows estrogen therapy induces DNA damage in ER+ breast cancer cells, which can be enhanced by PARP inhibition to improve treatment outcomes.

bioRxiv · Mar 16, 2023Cancer Biology

AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells

R. A. Hampsch, J. D. Wells, N. A. Traphagen, C. F. McCleery, J. L. Fields, K. Shee, L. M. Dillon, D. B. Pooler, L. D. Lewis, E. Demidenko, Y. H. Huang, J. D. Marotti, W. Kinlaw, T. W. Miller

This study shows that metformin promotes survival of dormant ER+ breast cancer cells by increasing mitochondrial respiration through fatty acid oxidation, suggesting caution in using AMPK activators with anti-estrogens.

bioRxiv · Jan 21, 2020Cancer Biology