Cancer BiologybioRxiv
AMPK activation by metformin promotes survival of dormant ER+ breast cancer cells
R. A. Hampsch, J. D. Wells, N. A. Traphagen…·T. W. Miller
This study shows that metformin promotes survival of dormant ER+ breast cancer cells by increasing mitochondrial respiration through fatty acid oxidation, suggesting caution in using AMPK activators with anti-estrogens.
DOI 10.1158/1078-0432.ccr-20-0269