Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2
E. Spears, J. E. Stanley, M. Shou, C. Dai, A. Bradley, L. Yin, X. Li, K. Sellick, G. Poffenberger, K. C. Coate, S. D. Shrestha, R. Jenkins, K. Sloop, K. T. Wilson, A. D. Attie, , E. D. Dean
This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.
bioRxiv · Aug 10, 2023Physiology