C. Dai

c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

Driving proteomic imbalance in malignancy provokes proteomic catastrophe and confers tumor suppression

This study shows that loss of HSF1 in MPNST cells causes proteomic imbalance and tumor suppression by inducing proteomic catastrophe through amyloidogenesis and mTORC1 inhibition.

NK Cell Exhaustion in Wilson's Disease Revealed by Single-cell RNA Sequencing Predicts the Prognosis of Cholecystitis

This study uses single-cell RNA sequencing to show NK cell exhaustion in Wilson's disease is linked to worse cholecystitis outcomes.

Identification of a distinct cluster of GDF15high macrophages exhibiting anti-inflammatory activities

The paper identifies a distinct cluster of GDF15high macrophages with anti-inflammatory properties using single-cell RNA sequencing and functional assays.

Pancreatic islet α cell function and proliferation requires the arginine transporter SLC7A2

This study identifies SLC7A2 as essential for α cell proliferation and glucagon secretion, linking arginine transport to metabolic regulation and HbA1c variation.

Immuno-Engineered Mitochondria for Efficient Therapy of Acute Organ Injuries via Modulation of Inflammation and Cell Repair

This study develops nMITO, engineered mitochondria that target inflammation and repair in acute organ injuries, showing efficacy in mouse models of myocardial, liver, and pancreatitis injuries.

Finite Element Modeling of Residual Hearing after Cochlear Implant Surgery in Chinchillas

This paper develops a finite element model of the chinchilla inner ear to study how CI electrode insertion angle affects residual hearing, finding minimal hearing loss with optimal angles.

Disrupted RNA editing in beta cells mimics early stage type 1 diabetes

Disrupted RNA editing in beta cells leads to an interferon response and diabetes, mimicking early-stage type 1 diabetes without viral infection.

Heat Shock Factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat-shock response

This study shows HSF1 enhances c-MYC transcription independently of the heat-shock response by recruiting GCN5 to promote histone acetylation.

Metagenomics revealing molecular profiling of microbial community structure and metabolic capacity in Bamucuo, Tibet

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

Highly efficient multiplex genome editing in dicot plants using improved CRISPR/Cas systems

This study improves CRISPR/Cas9 systems for efficient gene editing in dicot plants, achieving over 80% homozygous/bi-allelic mutations in tobacco and tomato.

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

Dietary Protein on Growth Performance, Serum Biochemical Index and offspring of Hu ewes in late pregnancy

This study examines the effects of different dietary protein levels on ewe growth, serum biochemistry, and lamb development during late pregnancy, finding no significant impact on growth performance but significant effects on metabolic indicators and lamb body measurements.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

A neural m6A/YTHDF pathway is required for learning and memory in Drosophila

This study identifies the m6A/YTHDF pathway's role in learning and memory in Drosophila by mapping m6A sites and showing their impact on translation and neural function.

Individualized ctDNA Fingerprints to Monitor Treatment Response and Recurrence in Multiple Cancer Types

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

Multi-site sampling and risk prioritization reveals the public health relevance of antibiotic resistance genes found in wastewater environments

This study assesses the public health risk of antibiotic resistance genes in wastewater by combining metagenomic analysis with risk prioritization across multiple countries.

Application of clinical genomic sequencing among Chinese advanced cancer patients to guide precision medicine decisions

This study evaluates the impact of clinical genomic sequencing (CWES) on treatment outcomes for Chinese stage IV cancer patients, finding improved progression-free survival in those following CWES recommendations.

Comprehensive analysis of potential immunotherapy genomic biomarkers in 1,000 Chinese patients with cancer

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.