PhysiologybioRxiv
Alternative (backdoor) androgen production and masculinization in the human fetus
P. J. O'Shaughnessy, J. P. Antignac, B. Le Bizec…·P. Fowler
This study identifies androsterone as the main backdoor androgen in human fetal circulation, showing it is synthesized in non-gonadal tissues and critical for masculinization.
DOI 10.1371/journal.pbio.3000002