Fitness Tradeoffs of Multidrug Efflux Pumps in Escherichia coli K-12 in Acid or Base, and with Aromatic Phytochemicals
Y. Liu, A. M. Van Horn, M. T. N. Pham, B. N. N. Dinh, R. Chen, S. D. R. Raphael, A. Paulino, K. Thaker, A. Somadder, C. C. Menke, Z. C. Slimak, J. L. Slonczewski
This study examines the fitness tradeoffs of multidrug efflux pumps in E. coli under acidic or basic conditions and in the presence of aromatic phytochemicals, showing that lipophilic non-acidic molecules select against AcrAB-TolC without benefiting other pumps.
bioRxiv · Jul 17, 2023 · PreprintMicrobiology