J. L. Slonczewski

Fitness Tradeoffs of Multidrug Efflux Pumps in Escherichia coli K-12 in Acid or Base, and with Aromatic Phytochemicals

This study examines the fitness tradeoffs of multidrug efflux pumps in E. coli under acidic or basic conditions and in the presence of aromatic phytochemicals, showing that lipophilic non-acidic molecules select against AcrAB-TolC without benefiting other pumps.

Enterococcus faecalis OG1RF Evolution at Low pH Selects Fusidate-sensitive Mutants in Elongation Factor G and at High pH Selects Defects in Phosphate Transport

This study shows that E. faecalis adapts to low pH by mutating elongation factor G, reducing fusidate resistance, and adapts to high pH by mutating phosphate transport genes, reducing acid tolerance.

Antibiotic Resistance Genes and Taxa Analysis from Mat and Planktonic Microbiomes of Antarctic Perennial Ice-covered Lake Fryxell and Lake Bonney

The paper analyzes antibiotic resistance genes and taxa in microbial communities from Antarctic ice-covered lakes, finding similar ARG levels to temperate water bodies but distinct distributions between mat and planktonic sources.

An Ohio State Scenic River Shows Elevated Antibiotic Resistance Genes, Including Acinetobacter Tetracycline and Macrolide Resistance, Downstream of Wastewater Treatment Plant Effluent

The study examines antibiotic resistance genes in a rural river downstream of a wastewater treatment plant, finding elevated ARGs including those linked to Acinetobacter baumannii.

Salicylate, Bile Acids and Extreme Acid Cause Fitness Tradeoffs for Multidrug Pumps in Escherichia coli K-12

This study investigates how salicylate, bile acids, and extreme acid affect the fitness of multidrug efflux pumps in E. coli, revealing tradeoffs and conditions under which these pumps confer advantages or costs.

Genomic and phenotypic evolution of Escherichia coli in a novel citrate-only resource environment

This study examines the genomic and phenotypic evolution of Escherichia coli in a citrate-only environment, identifying copy-number variations and transposable elements as key factors, while noting persistent physiological mismatches.

Benzoate-Tolerant Escherichia coli Strains from Experimental Evolution Lose the Gad Regulon, Multi-Drug Efflux Pumps, and Hydrogenases

This study shows that benzoate-tolerant E. coli strains lose MDR efflux pumps, hydrogenases, and the Gad regulon while upregulating porins, leading to increased antibiotic sensitivity.

Benzoate and Salicylate Tolerant Strains Lose Antibiotic Resistance during Laboratory Evolution of Escherichia coli K-12

This study shows that laboratory evolution of E. coli K-12 under benzoate or salicylate stress leads to loss of antibiotic resistance and MDR gene regulators.