Cancer BiologybioRxiv
Repurposing the antidepressant sertraline as SHMT inhibitor to suppress serine/glycine synthesis addicted breast tumor growth.
S. L. Geeraerts, K. R. Kampen, G. Rinaldi…·K. De Keersmaecker
This study repurposes sertraline as an inhibitor of serine hydroxymethyltransferase to target serine/glycine synthesis in breast cancer, showing synergistic antitumor effects with mitochondrial inhibitors.
DOI 10.1158/1535-7163.mct-20-0480