Kaiqiang Ye

Ultra-fast and scalable high-resolution full-length single-cell RNA sequencing using CHART-seq

CHART-seq enables ultra-fast, scalable full-length single-cell RNA sequencing with improved gene detection and isoform annotation compared to existing methods.

Decomap-seq enables efficient and reliable retrieval of spatial transcripts

Decomap-seq improves spatial transcriptomics by enhancing transcript capture efficiency through structural optimization of probe design.

Unbiased Single-Cell Transcriptome-Proteome Co-Profiling Reveals Malignant Dormancy and Post-Transcriptional Buffering of CTCs

The paper develops a method to co-profile transcriptomes and proteomes of rare CSF-CTCs, revealing malignant dormancy and post-transcriptional buffering as key mechanisms of treatment resistance.

snCED-seq: High-fidelity cryogenic enzymatic dissociation of nuclei for single-nucleus RNA-seq of FFPE tissues

The paper introduces snCED-seq, a method for isolating high-quality nuclei from FFPE tissues, showing improved RNA retention and gene detection compared to traditional methods.

Single-nucleus RNA sequencing revealed the impact of post-mortem interval on the cellular component and gene expression analysis of mouse brains

This study uses snRNA-seq to analyze how post-mortem interval affects cellular components and gene expression in mouse brain tissues.

Defining specific cell states of MPTP-induced Parkinson's disease by single-nucleus RNA sequencing

This study uses single-nucleus RNA sequencing to identify PD-specific cell states in MPTP-induced mouse brains, revealing changes in astrocytes, endothelial cells, and medium spiny neurons.