BiophysicsbioRxiv
Modeling reveals the strength of weak interactions in stacked ring assembly
Leonila Lagunes, Koan Briggs, Paige Martin-Holder…·Eric J. Deeds
The paper develops a mathematical model of stacked trimer assembly, revealing that strong interaction affinities can lead to kinetic trapping, suggesting evolutionary pressure for weaker interactions in stacked ring structures.
DOI 10.1016/j.bpj.2024.05.015