Structural basis for the intestinal protocadherin-based intermicrovillar adhesion complex
Akinobu Senoo, Pablo Adrian Guillen-Poza, Karin Fujishima, Hirofumi Kosuge, Takamasa Doumoto, Keisuke Kasahara, Tomohito Tanihara, Yuya Yoshida, Saeko Yanaka, Makoto Nakakido, Satoru Nagatoishi, Katsumi Maenaka, Shigehiro Ohdo, Naoya Matsunaga, Rubén Hervás, , José M. M. Caaveiro
The paper determines the Cryo-EM structure of the intestinal IMAC complex, revealing its heterotetrameric composition and structural features that enable microvilli adhesion and resilience to shear stress.
bioRxiv · May 14, 2026 · PreprintBiophysics