Katsumi Maenaka

This study uses cryo-ET to analyze native, active SARS-CoV-2 virions, revealing a transient open-trimer prefusion state and hidden spike flexibility with implications for vaccine design.

This study determines the cryo-EM structure of HIV-1 capsid lattice with lenacapavir, showing how it disrupts capsid formation and function during virion maturation.

The paper validates a cell-free nucleosome assembly method using ExACT and confirms its structural fidelity through cryo-EM and deep-learning-based model quality scoring.

This study reveals how rabies virus P protein inhibits interferon signaling by selectively binding to phosphorylated STAT1 tetramers, stabilizing them and preventing DNA binding.

The paper determines the Cryo-EM structure of the intestinal IMAC complex, revealing its heterotetrameric composition and structural features that enable microvilli adhesion and resilience to shear stress.

This study evaluates AddaS03 as an adjuvant for a WNV subunit vaccine, showing it elicits higher neutralizing antibody titers and provides full protection in mice compared to Alhydrogel.

This study identifies herpesvirus protein kinases that mimic CDK regulation, showing their role in viral replication and pathogenicity.

This study investigates how morbilliviruses use SLAM receptors across species, finding that most can use multiple SLAMs except human SLAM, and that MV adapts to bat SLAM with a single mutation.

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

This study evaluates the thermostability and binding properties of scFv fragments from FDA-approved antibodies, showing that stable scFvs maintain antigen binding.

This paper shows HLA-G2 induces tolerance in human monocytes and dendritic cells by upregulating PD-L1 through LILRB2 binding, suggesting it as a target for immune checkpoint therapy.