Author

Keith Lane

Neural Stem Cell Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alison GoateiD· 2 shared Celeste M M. KarchiD· 2 shared Kathryn R. BowlesiD· 2 shared M. Catarina SilvaiD· 2 shared Rebecca Chowdhury· 2 shared Sally TempleiD· 2 shared Stephen J. HaggartyiD· 2 shared Steven Lotz· 2 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alison GoateORCID

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Author profile →

2 papers

Recent·Most cited

Integrated Manufacturing Platform for Cortical Organoids Reveals Early Phosphatase and Prefoldin Dysregulation in MAPT V337M Neurons

Taylor B. Bertucci, Kathryn R. Bowles, Steven Lotz, Shiraz Bheda, Le Qi, Farhad Farjood, Katherine Whitton, Susan K. Goderie, Susan M. Borden, Amelia Rossi, Kate Tubbesing, Chiara Pedicone, Laura Maria Oja, Keith Lane, Ryan Lotz, , Sally Temple

The paper develops a scalable cortical organoid platform with quality control metrics and identifies early dysregulation of phosphatase and prefoldin genes in FTD-tau neurons.

bioRxiv · Jul 11, 2023 · PreprintNeuroscience

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with MAPT mutation.

Kathryn R. Bowles, M. Catarina Silva, Kristen R. Whitney, Taylor B. Bertucci, Jacob C. Garza, Nathan C. Boles, Kevin H. Strang, Sidhartha K. Mahali, Jacob A. Marsh, Cynthia Chen, Derian A. Pugh, Yiyuan Liu, Joshua E. Berlind, Jesse D. Lai, Susan K. Goderie, , Sally Temple

This study shows that glutamatergic dysfunction occurs before neuron loss in cerebral organoids with MAPT mutations, suggesting therapeutic targets for FTD.

bioRxiv · Feb 3, 2021 · PreprintNeuroscience