Identification of a new ORF3a-E fusion subgenomic RNA of SARS-CoV-2 and its biological features in the infection process
Yifan Zhang, Huiwen Zheng, Jing Li, Xin Zhang, Jiali Li, Heng Li, Xin Zhao, Zihan Zhang, Yingyan Li, Keqi Chen, Shasha Peng, Ying Zhang, Haijing Shi, Longding Liu
The paper identifies a new SARS-CoV-2 subgenomic RNA, ORF3a-E-sgRNA, which enhances viral replication and immune evasion by promoting translation and host protein interactions.
Frontiers in Immunology · Aug 15, 2025Peer-reviewedMicrobiology