Ref(2)P/p62 protein pleomorphism confers tissue-specific function
Yan Yan, Kai Zhang, Gabrielle Pycior, Pablo Adrian Guillen-Poza, Rubén Hervás, Paulo Leal, Kexi Yi, Zulin Yu, Ying Zhang, Laurence A. Florens, Jay R. Unruh, Kausik Si
One Drosophila Ref(2)P polypeptide takes different structures in midgut and muscle, driving autophagy or mitochondria-associated degradation; deleting disordered region IDR2 switches muscle Ref(2)P to midgut state.
bioRxiv · Oct 5, 2026 · PreprintCell Biology✦ In-depth digest