BiochemistrybioRxivPreprint
A GPCR-G protein-β-arrestin megacomplex induced by an allosteric modulator
Guodong He, Qinxin Sun, Xinyu Xu…·Xiangyu Liu
This study determines the structure of a GPCR-G protein-β-arrestin complex stabilized by an allosteric modulator, showing a novel binding mode that allows coexistence with G protein signaling.