Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
Jagat K Chhipi-Shrestha, Tilman Schneider‐Poetsch, Takehiro Suzuki, Mari Mito, Khalid Khan, Naoshi Dohmae, Shintaro Iwasaki, Minoru Yoshida
The paper shows splicing modulators cause translational repression by inducing condensate-prone intron-derived proteins that inhibit mTORC1 and trigger proteotoxic stress.
Cell chemical biology · Sep 13, 2021Peer-reviewedMolecular Biology