Naoshi Dohmae

This study reports cryo-EM structures of BAM-BepA complexes and identifies loop conformations that regulate BepA's dual function in substrate triage.

This paper identifies CgLhcf9 as a negative regulator of energy-dependent NPQ in the diatom Chaetoceros gracilis, showing it suppresses NPQ under specific light and CO2 conditions to improve growth.

This study presents the cryo-EM structure of TOK1, revealing its unique domain architecture and lipid-mediated gating mechanism through structural and functional analyses.

The paper identifies a new class of proteomes, USURPs, formed by upstream overlapping ORFs that cis-regulate protein-coding sequences and are linked to human diseases.

This study shows that larval protein restriction in Drosophila extends adult lifespan by reducing storage proteins, which control translation and are enriched in aromatic amino acids.

The paper elucidates the cleavage cascade of FecR that mediates ferric citrate signaling via the TonB-FecA axis in Escherichia coli.

The paper identifies a plant immune receptor, SCORE, that recognizes CSP peptides and shows polymorphisms across species, enabling the design of synthetic variants for broad pathogen detection.

The paper identifies a novel chlorophyll a/b-binding protein, RedCAP, in the PSI-LHCI supercomplexes of Galdieria sulphuraria, highlighting its distinct binding properties and spectral characteristics compared to LHC proteins.

The paper determines the structure of PSI-LHCI from Cyanidium caldarium and investigates its evolutionary relationships with other red-lineage LHCs.

This study investigates the effects of eIF5A hypusination inhibition on mitochondrial function and identifies MPV17L2 as a key regulator involved in mitochondrial integrity.

This study identifies METTL18 as a histidine methyltransferase that modifies RPL3, slowing ribosome translocation on tyrosine codons to aid protein folding and prevent aggregation.

The paper examines changes in PSD protein composition across development in mice and primates, linking these changes to autism spectrum disorder.

The paper shows splicing modulators cause translational repression by inducing condensate-prone intron-derived proteins that inhibit mTORC1 and trigger proteotoxic stress.

The paper investigates the role of H3K9me2 in 3D genome organization by analyzing its distribution, transcriptome, and chromatin structure in mouse embryonic stem cells with altered H3K9 methyltransferase activity.

The paper presents the cryo-EM structure of the human LRRC8A protein, revealing its trimer-of-dimers assembly and structural features relevant to its function as a volume-regulated anion channel.