Cancer BiologybioRxivPreprint
YAP/TEAD4-regulated placental alkaline phosphatases ALPP and ALPPL2 are immunosuppressive ectonucleotidases modulated by MAPK inhibitors
J MARTIN, Bruce Huang, Tobias Ehrenberger…·David Bauché
This study identifies YAP/TEAD4 as a regulator of ALPP/L2 expression and shows that MAPK inhibitors enhance their expression, improving ADC efficacy through immunomodulation.
DOI 10.1101/2025.10.15.682438