Author

Kodai Kurihara

Shinshu University

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Biology Disciplines

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Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein structure· 1

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Guanyu LiaoiD· 1 shared Koji UmezawaiD· 1 shared Michael H. HechtiD· 1 shared Mina Nagahara· 1 shared Ryoichi AraiiD· 1 shared Sha Tao· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperSynthetic Biology

Guanyu LiaoORCID

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1 paper

Recent·Most cited

Synthetic BiologybioRxivPreprintDec 9, 2025

Engineering a Covalent Linkage into a Dimeric De Novo Enzyme Reveals a Novel Life-Sustaining Mechanism

Guanyu Liao, Sha Tao, Mina Nagahara…·Michael H. Hecht

The paper engineers a covalent linkage into a de novo enzyme, revealing that the modified protein rescues cells through upregulating siderophore biosynthesis rather than catalyzing iron release.

DOI 10.64898/2025.12.09.693225

E. coliprotein structure

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