Author

Komal Nayak

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Matthias ZilbaueriD· 4 shared Aurélie CenieriD· 2 shared Alì MirazimiiD· 1 shared Anca DorhoiiD· 1 shared Andrew E. FirthiD· 1 shared Anne Balkema‐BuschmanniD· 1 shared April Rose FosteriD· 1 shared Ateequr RehmaniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

Matthias ZilbauerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Flexibility and modulation of translation initiation in enterovirus genomes

Rhian L. O’Connor, Georgia M. Cook, Jacqueline Hankinson, Ksenia V. Fominykh, Samantha H. Cheng, Daniel A Nash, Aurélie Cenier, Komal Nayak, Stephen C. Graham, Janet Elwyn Deane, Matthias Zilbauer, Andrew E. Firth, Valeria Lulla

This study shows enteroviruses can use two upstream AUGs for translation initiation, with the second AUG providing a competitive advantage in specific host environments.

PLoS Pathogens · Feb 9, 2026Peer-reviewedMicrobiology

Human Milk Oligosaccharides Modulate Inflammatory Responses and Lipid Metabolism in a Human Intestinal Organoid Model

Ellie Slater, Jaesub Park, Thomas W. Dennison, Tim N. Mak, Igor Bendik, Ateequr Rehman, Bernd Mußler, Frank Wiens, Komal Nayak, Matthias Zilbauer

This study examines how a blend of human milk oligosaccharides affects intestinal epithelial cells in fetal and pediatric organoids, showing stage-specific responses and anti-inflammatory effects.

Clinical Nutrition · Dec 27, 2025Peer-reviewedCell Biology

Reconstructing bat antiviral immunity using epithelial organoids

Max J. Kellner, Vanessa Monteil, Patrick Zelger, Gang Pei, Jie Jiao, Masahiro Onji, Komal Nayak, Matthias Zilbauer, Anne Balkema‐Buschmann, Anca Dorhoi, Alì Mirazimi, Josef Martin Penninger

This study uses bat epithelial organoids to investigate antiviral immunity differences between bats and humans, revealing unique interferon responses and implications for viral pathogenesis.

Nature Immunology · May 21, 2025Peer-reviewedImmunology

Culture Associated DNA Methylation Changes Impact on Cellular Function of Human Intestinal Organoids

Rachel D. Edgar, Francesca Marta Perrone, April Rose Foster, Felicity Payne, Sophia Lewis, Komal Nayak, Judith Kraiczy, Aurélie Cenier, Franco Torrente, Camilla Salvestrini, Robert B. Heuschkel, Kai Oliver Hensel, Rebecca Harris, D. Leanne Jones, Daniel R. Zerbino, Matthias Zilbauer

This study shows that long-term culture of human intestinal organoids leads to DNA methylation changes, altered gene expression, and functional shifts, suggesting potential confounding effects in research.

Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2022Peer-reviewedGenomics