Valeria Lulla

This study identifies HSV-1 protein pUL56 as responsible for removing voltage-gated ion channels from neuronal plasma membranes, disrupting calcium signaling and neuronal activity.

This study identifies ZNFX1 as a multifunctional enzyme in innate immunity that couples RNA sensing to ubiquitin signaling and assembles into higher-order structures for signal amplification.

This study identifies cleavage sites and processing dynamics of astrovirus polyproteins, revealing conserved and divergent features between classical and non-classical strains.

This study investigates RNA replication dynamics in astroviruses using high-throughput sequencing, revealing a conserved premature termination model for subgenomic RNA production.

This study shows enteroviruses can use two upstream AUGs for translation initiation, with the second AUG providing a competitive advantage in specific host environments.

The paper investigates the structural and mechanistic details of translation initiation on the enterovirus Type 1 IRES using cryo-electron microscopy, revealing key RNA-RNA interactions critical for viral replication.

This study identifies di-arginine motifs in the N-terminal domain of astrovirus nsP1a that mediate ER retention and replication complex formation.

The paper identifies the stem loop 2 motif as a vulnerable site in SARS-CoV-2 that can be targeted by antisense oligonucleotides to inhibit replication and infection.