Josef Martin Penninger

This study shows that endogenous insulin in pancreatic cancer tumors affects tumor growth and systemic metabolism, with differential effects based on diet and mouse sex.

The paper identifies three urinary biomarkers for clear cell renal cell carcinoma using multi-omics analysis and develops a diagnostic score with 96% accuracy.

This study shows that tumor sialylation suppresses anti-cancer immunity in breast cancer by altering immune cell interactions and checkpoint ligands, and that inhibiting sialylation enhances immune response and therapy effectiveness.

This study shows human macrophages take up extracellular citrate but do not use it as a carbon source, instead modulating glutamine metabolism and immune responses during infection.

This study identifies MED13 and DDX60 as critical host factors for SARS-CoV-2 infection through a haploid genetic screen in mouse cells.

This study shows that Ddx3x is essential for B-cell development in mice, with loss leading to developmental blocks and defects in immunoglobulin rearrangement.

This study investigates long-term intestinal epithelial changes after acute protein-energy malnutrition using multi-omics approaches and identifies microbial lipid metabolites and epigenetic factors as key drivers of persistent Paneth cell dysfunction.

This study fuses blood vessel organoids with human pancreatic islets, showing improved insulin response over time in two donors.

This study identifies CLEC18A as a regulator of clear cell renal cell carcinoma progression by interacting with sulfated GAGs and shows its expression is linked to improved patient survival.

This study uses bat epithelial organoids to investigate antiviral immunity differences between bats and humans, revealing unique interferon responses and implications for viral pathogenesis.

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

This study maps the cell state transitions during human blood vessel organoid development using single-cell transcriptomics and identifies key regulators and disease associations.

This study examines neuropathological changes in the olfactory bulb and tract of COVID-19 patients, finding no significant inflammation but age-related decline in anti-CD68 reactivity and mild increases in phospho-Syn and phospho-tau signals in affected brains.

This study shows PRV hijacks DDX3X in sensory neurons to cause 'mad itch' and immune suppression, aiding viral spread.

This study demonstrates that BH4 deficiency exacerbates PD-related stressors and that BH4 augmentation protects dopaminergic neurons in multiple models.

This study identifies the HUSH complex as an epigenetic regulator of protocadherin expression in neurons, affecting brain development and neuronal diversity in mice and humans.

This paper shows that clinical-grade soluble ACE2 effectively inhibits multiple SARS-CoV-2 variants, including VOCs, in cell cultures and across independent labs.

This study identifies PCYT2 as critical for muscle health and aging, showing its deficiency causes muscle weakness and aging, and demonstrates therapeutic potential through AAV-based delivery.

The paper shows clinical grade recombinant ACE2 effectively neutralizes SARS-CoV-2 Omicron in VeroE6 cells, outperforming neutralization against reference isolates.

This paper presents a method for genome-wide spatial mRNA analysis in FFPE tissues, demonstrating its ability to delineate anatomical regions and analyze transcriptomic signatures in ovarian carcinosarcoma.

This study identifies FIBCD1 as a conserved receptor for chondroitin sulphate proteoglycans in the brain ECM, linking it to neurodevelopmental disorders through genetic and functional analyses.

The paper identifies two lectins, Clec4g and CD209c, that bind to conserved glycosylation sites on SARS-CoV-2 Spike and reduce viral infections.

The paper benchmarks crosslinking mass spectrometry search engines using synthetic peptide libraries, revealing significant variation in false discovery rates across different validation strategies.

The paper identifies lnc-NR2F1 as a pro-neurogenic lncRNA mutated in neurodevelopmental disorders through genetic and functional studies.

The paper develops an algorithm to predict functional neuroanatomical maps by integrating gene expression, connectivity data, and genetic metadata from mouse and human sources.