Author

Kozeta Libohova

Wayne State University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5

Signature Assays, Organisms & Methods

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Organism:Drosophila· 5 Approach:experimental assay· 5 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Sokol V. TodiiD· 5 shared Alyson L. SujkowskiiD· 3 shared Nikhil C. PateliD· 3 shared Kristin RichardsoniD· 2 shared Ryan O Dulay· 2 shared Wei‐Ling TsouiD· 2 shared Anna J. Barget· 1 shared Autumn C. Harris· 1 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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5 shared papersNeuroscience

Sokol V. TodiORCID

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Author profile →

5 papers

Recent·Most cited

Insights into Dentatorubral-Pallidoluysian Atrophy from a new Drosophila model of disease

Matthew V. Prifti, Oluwademilade Nuga, Ryan O Dulay, Nikhil C. Patel, Truman Kula, Kozeta Libohova, Autumn Jackson-Butler, Wei‐Ling Tsou, Kristin Richardson, Sokol V. Todi

This paper develops a Drosophila model of DRPLA by expressing human ATN1 with normal or pathogenic polyglutamine repeats, showing that pathogenic ATN1 causes toxicity and identifies potential therapeutic targets.

Neurobiology of Disease · Feb 5, 2025Peer-reviewedNeuroscience

A phenotypically robust model of Spinal and Bulbar Muscular Atrophy in Drosophila

Kristin Richardson, Medha Sengupta, Alyson L. Sujkowski, Kozeta Libohova, Autumn C. Harris, Robert J. Wessells, Diane E. Merry, Sokol V. Todi

This paper develops a Drosophila model of SBMA by expressing human AR with pathogenic polyQ repeats, showing motor neuron degeneration and aggregation linked to androgen dependence.

Journal of Neuroscience Research · Dec 8, 2023Peer-reviewedNeuroscience

Phenotypic defects from the expression of wild-type and pathogenic TATA-Binding Proteins in new Drosophila models of Spinocerebellar Ataxia Type 17

Nikhil C. Patel, Nadir Alam, Kozeta Libohova, Ryan O Dulay, Sokol V. Todi, Alyson L. Sujkowski

This study introduces two new Drosophila models expressing human TBP with polyQ repeats to study SCA17 pathology and its effects on neurodegeneration.

G3 Genes Genomes Genetics · Aug 8, 2023Peer-reviewedNeuroscience

Lysine 117 on ataxin-3 modulates toxicity in Drosophila models of Spinocerebellar Ataxia Type 3

Jessica R. Blount, Nikhil C. Patel, Kozeta Libohova, Autumn L. Harris, Wei‐Ling Tsou, Alyson L. Sujkowski, Sokol V. Todi

This study investigates the role of lysine 117 ubiquitination in modulating toxicity of pathogenic Atxn3 in Drosophila models of SCA3, finding that mutating K117 mildly enhances toxicity and aggregation.

bioRxiv · May 30, 2023 · PreprintNeuroscience

Druggable genome screen identifies new regulators of the abundance and toxicity of ATXN3, the Spinocerebellar Ataxia Type 3 disease protein

Naila S. Ashraf, Joanna R. Sutton, Yemen Yang, Bedri Ranxhi, Kozeta Libohova, Emily D. Shaw, Anna J. Barget, Sokol V. Todi, Henry Lauris Paulson, Maria do Carmo Costa

The paper identifies 15 druggable genes that modulate ATXN3 levels and toxicity in SCA3, with FBXL3/SCF pathway showing potential as a therapeutic target.

Neurobiology of Disease · Nov 26, 2019Peer-reviewedNeuroscience