Insights into Dentatorubral-Pallidoluysian Atrophy from a new Drosophila model of disease
Matthew V. Prifti, Oluwademilade Nuga, Ryan O Dulay, Nikhil C. Patel, Truman Kula, Kozeta Libohova, Autumn Jackson-Butler, Wei‐Ling Tsou, Kristin Richardson, Sokol V. Todi
This paper develops a Drosophila model of DRPLA by expressing human ATN1 with normal or pathogenic polyglutamine repeats, showing that pathogenic ATN1 causes toxicity and identifies potential therapeutic targets.
Neurobiology of Disease · Feb 5, 2025Peer-reviewedNeuroscience