NeuroscienceNeurobiology of DiseasePeer-reviewed
Insights into Dentatorubral-Pallidoluysian Atrophy from a new Drosophila model of disease
Matthew V. Prifti, Oluwademilade Nuga, Ryan O Dulay…·Sokol V. Todi
This paper develops a Drosophila model of DRPLA by expressing human ATN1 with normal or pathogenic polyglutamine repeats, showing that pathogenic ATN1 causes toxicity and identifies potential therapeutic targets.
6 citations